Ribonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DN

DNA is the central repository of genetic information in the cell, yet it is under constant attack by chemical mutagens, radiation and other processes. Cells the

The crystal structure and biochemical studies of Bacillus stearothermophilus UvrA presented in this thesis provide molecular understanding of the ATP-modulated