Download or read book Development of Multicomponent Assembly Processes and Their Application to the Synthesis of Novel Heterocyclic Scaffolds and the Total Synthesis of Actinophyllic Acid written by Brett Adam Granger and published by . This book was released on 2013 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several novel multicomponent assembly processes have been developed for the preparation of a diverse array of complex heterocyclic systems from relatively simple starting materials. These studies resulted in the discovery of a new quinazolone forming reaction, which was applied to the one-step synthesis of the quinazolinocarboline alkaloid rutaecarpine. Biological screening of these complex heterocycles culminated in the identification of a potent sigma-2 receptor ligand. A novel N-acyliminium ion mediated cascade reaction was employed for the concise synthesis of (±)-actinophyllic acid. The completion of the synthesis relied on the development of a reaction sequence that avoided a potentially detrimental fragmentation process. Furthermore, several anti-cancer compounds were identified through a diverted total synthesis approach.