p53 Suppressor Gene
Author | : Tapas Mukhopadhyay |
Publisher | : Springer Science & Business Media |
Total Pages | : 189 |
Release | : 2013-06-29 |
ISBN-10 | : 9783662222751 |
ISBN-13 | : 3662222752 |
Rating | : 4/5 (752 Downloads) |
Download or read book p53 Suppressor Gene written by Tapas Mukhopadhyay and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.