Download or read book Neuroimmunomodulation written by Samuel McDonald McCann and published by . This book was released on 1997-12-31 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discipline of neuroimmunomodulation is devoted to interactions between the immune nervous systems at all levels and includes observation on brain, pituitary, peripheral nervous system and immune cells. Nitric oxide synthase is contained within neurons in the brain and modifies behavioural and hormonal responses by acting on other neurons and on release of peptides and other transmitters through activation of guanylate cyclase and cyclooxygenase. Increases in this and in expression of proinflammatory cytokines can contribute to damage in patients with multiple sclerosis, Parkinsonism, meningitis, stroke, and Alzheimer's disease.