Protein Homeostasis, Second Edition

Protein Homeostasis, Second Edition
Author :
Publisher : Perspectives Cshl
Total Pages : 562
Release :
ISBN-10 : 1621822966
ISBN-13 : 9781621822967
Rating : 4/5 (967 Downloads)

Book Synopsis Protein Homeostasis, Second Edition by : Richard I. Morimoto

Download or read book Protein Homeostasis, Second Edition written by Richard I. Morimoto and published by Perspectives Cshl. This book was released on 2019 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting in the aggregation of misfolded proteins-a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on how the proteostasis network functions in healthy cells and the diseases that result when protein quality control goes awry. The contributors examine the relevant biochemical attributes of proteins (e.g., solubility), the functions of normal protein aggregates (e.g., biofilm formation in bacteria), and the various heat shock proteins, chaperones, translocation machineries, proteasomes, signaling factors, and transcriptional programs involved in proteostasis. The roles of specific subcellular structures-the endoplasmic reticulum, mitochondria, ribosomes, lysosomes, and cytoplasm-in protein quality control are covered, as is the regulation of proteostasis at the organismal level (e.g., via neuronal activity). Discussions of the responses by cells when errors in protein quality control occur, the medical disorders that can result (e.g., Alzheimer disease), and pharmacologic approaches to ameliorate protein conformational disorders are also included. This book is therefore an essential reference for biochemists, cell biologists, and all biomedical scientists wishing to understand the pathological consequences of and potential therapies for proteostasis deficiencies in common human diseases.

Protein Homeostasis, Second Edition Related Books

Protein Homeostasis, Second Edition
Language: en
Pages: 562
Authors: Richard I. Morimoto
Categories: Medical
Type: BOOK - Published: 2019 - Publisher: Perspectives Cshl

GET EBOOK

The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, co
Anatomy and Physiology
Language: en
Pages: 0
Authors: J. Gordon Betts
Categories:
Type: BOOK - Published: 2013-04-25 - Publisher:

GET EBOOK

Textbook Of Structural Biology (Second Edition)
Language: en
Pages: 610
Authors: Anders Liljas
Categories: Science
Type: BOOK - Published: 2016-09-27 - Publisher: World Scientific

GET EBOOK

This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research
Protein Homeostasis Diseases
Language: en
Pages: 452
Authors: Angel L. Pey
Categories: Science
Type: BOOK - Published: 2020-02-13 - Publisher: Academic Press

GET EBOOK

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biol
Molecular Biology of the Cell
Language: en
Pages: 0
Authors:
Categories: Cells
Type: BOOK - Published: 2002 - Publisher:

GET EBOOK