Download or read book Structural and Biochemical Studies of Bacterial Nucleotide Excision Repair Enzymes: UvrA and UvrC. written by Yoshihiko Inuzuka and published by . This book was released on 2007 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: From biochemical studies using E. coli, it is concluded that UvrC is responsible for incision at both sides of a lesion, and 3' incision occurs first followed by 5' incision. In our model system B. st., however, 3' incision is deficient while 5' incision occurs without the necessary 3' incision. The first example of this unusual incision mechanism was published only recently, and B. st. is the second organism that does not seem to possess the efficient 3' incision activity.